Abstract The current advanced analysis techniques for steel frames generally use structural analyses with geometric and material nonlinearities to capture the collapse strength of the steel frame. Unfortunately, the true strength of a steel frame cannot be predicted with accuracy because of the uncertainties of the most significant design variables. Building codes of steel structures apply a resistance factor to account for the uncertainties present in the design variables and thus ensure a target level of structural reliability. This article examines the reliability of planar steel frames subject to gravitational loads by advanced structural analysis (second-order inelastic analysis). To calculate the collapse probability of planar steel frames, we utilized the first-order reliability method (FORM). The advanced analyses were performed using the program MASTAN2 and considered the geometric nonlinearities and inelasticity of the steel. The collapse probabilities of planar steel frames were evaluated and the adequacy of the resistance factor applied was discussed. The current inelastic design procedure of ANSI 360 reduces the yield strength and stiffness of all members by a factor of 0.90. Thus, the present study suggests that the adopted resistance factor must be equal to 0.85 for the target reliability index equal to 3.0, or it must be equal to 0.69 for the target reliability index equal to 3.8.